RFX3 Modulation of FOXJ1 regulation of cilia genes in the human airway epithelium

  title={RFX3 Modulation of FOXJ1 regulation of cilia genes in the human airway epithelium},
  author={Lukas Didon and Rachel K. Zwick and Ion Wa Chao and M. Scott Walters and Rui Wang and Neil R. Hackett and Ronald G. Crystal},
  booktitle={Respiratory research},
BACKGROUND Ciliated cells play a central role in cleansing the airways of inhaled contaminants. They are derived from basal cells that include the airway stem/progenitor cells. In animal models, the transcription factor FOXJ1 has been shown to induce differentiation to the ciliated cell lineage, and the RFX transcription factor-family has been shown to be necessary for, but not sufficient to induce, correct cilia development. METHODS To test the hypothesis that FOXJ1 and RFX3 cooperatively… CONTINUE READING
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