RFT2 is overexpressed in esophageal squamous cell carcinoma and promotes tumorigenesis by sustaining cell proliferation and protecting against cell death.

@article{Jiang2014RFT2IO,
  title={RFT2 is overexpressed in esophageal squamous cell carcinoma and promotes tumorigenesis by sustaining cell proliferation and protecting against cell death.},
  author={Xing-ran Jiang and Xi-Ying Yu and J. Fan and L. Guo and Changjun Zhu and W. Jiang and S. Lu},
  journal={Cancer letters},
  year={2014},
  volume={353 1},
  pages={
          78-86
        }
}
  • Xing-ran Jiang, Xi-Ying Yu, +4 authors S. Lu
  • Published 2014
  • Biology, Medicine
  • Cancer letters
  • Human riboflavin transporter 2 (RFT2, also termed as SLC52A3) was recently identified as a susceptibility gene to esophageal squamous cell carcinoma (ESCC), however, its expression and biologic function has remained unclear in ESCC. In this study, we demonstrated that RFT2 was frequently overexpressed in tumor samples compared with normal adjacent tissue in ESCC patients. Knockdown of RFT2 in ESCC cells resulted in decreases of intracellular flavin status, mitochondrial membrane potential and… CONTINUE READING
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