• Biology
  • Published 2005

REVIEWS: CURRENT TOPICS The role of mitochondrial DNA in the development of type 2 diabetes caused by fetal malnutrition B

@inproceedings{Lee2005REVIEWSCT,
  title={REVIEWS: CURRENT TOPICS The role of mitochondrial DNA in the development of type 2 diabetes caused by fetal malnutrition B},
  author={Yun Yong Lee and Kyong Soo Park and Youngmi Kim Pak and Hong Kyu Lee},
  year={2005}
}
Epidemiological studies have revealed strong and reproducible links between indices of poor fetal growth and susceptibility to the development of glucose intolerance and insulin resistance syndrome in adult life. To explain these associations, the thrifty phenotype hypothesis has been proposed. Mitochondrial DNA abnormalities have been known to cause insulin deficiency, insulin resistance and diabetes mellitus. In this review, we propose that mitochondrial dysfunction is a link between… CONTINUE READING