Corpus ID: 37475975

REVIEWARTICLE PANDAS : a new disease ?

  title={REVIEWARTICLE PANDAS : a new disease ?},
  author={Sheila Knupp Oliveira},
Objective: To establish the diagnostic criteria for PANDAS and to analyze the existing evidence regarding its etiopathogenesis, treatment and prophylaxis. Sources: Review of the scientific literature through a MEDLINE search carried out between 1989 and 2006. Summary of the findings: The diagnostic criteria for PANDASwere established nearly 10 years ago, but a lot of controversy still exists over the actual existence of this new pediatric disease. The name of this new disease, supposedly of… Expand


PANDAS: current status and directions for research
The recognition of the five criteria for PANDAS by Swedo et al established a homogenous subgroup of children with childhood onset obsessive–compulsive disorder (OCD) and/or tic disorders that is theorized to occur as a result of post-streptococcal autoimmunity in a manner similar to that of Sydenham's chorea. Expand
Infection-triggered anorexia nervosa in children: clinical description of four cases.
  • M. Sokol
  • Medicine
  • Journal of child and adolescent psychopharmacology
  • 2000
There may be a link between infectious disease and some cases of Anorexia nervosa, which raises the possibility of new treatment. Expand
The pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS) subgroup: separating fact from fiction.
Questions about the veracity of data presented in this issue of Pediatrics are raised and a brief literature review and clarification of the guidelines for management of a patient in the PANDAS subgroup are provided. Expand
The pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS) etiology for tics and obsessive-compulsive symptoms: hypothesis or entity? Practical considerations for the clinician.
Until more definitive scientific proof is forthcoming, there seems to be insufficient evidence to support routine microbiologic or serologic testing for group A streptococcus in children who present with neuropsychiatric symptoms or the clinical use of antibiotic or immune-modifying therapies in such patients. Expand
Is Tourette's syndrome an autoimmune disease?
We provide a review of recent research findings which support the involvement of autoimmunity in childhood-onset tic disorders, in particular the presence of antineuronal autoantibodies, D8/17 BExpand
Anti-brain antibodies in PANDAS versus uncomplicated streptococcal infection.
The results suggest that antibrain antibodies are present in children with PANDAS that cannot be explained merely by a history of GABHS infection. Expand
Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections: clinical description of the first 50 cases.
The working diagnostic criteria appear to accurately characterize a homogeneous patient group in which symptom exacerbations are triggered by GABHS infections. Expand
PANDAS: a commentary.
It is concluded that PANDAS is an intriguing hypothesis that requires further confirmation, and antibodies produced against GABHS cross-react with neuronal cells, in a process involving molecular mimicry. Expand
Case study: a new infection-triggered, autoimmune subtype of pediatric OCD and Tourette's syndrome.
The hypothesis is that infections with group A beta-hemolytic streptococci, among others, may trigger autoimmune responses that cause or exacerbate some cases of childhood-onset obsessive-compulsive disorder (OCD) or tic disorders (including Tourette's syndrome). Expand
Sydenham's chorea--clinical and evolutive characteristics.
Despite the regular use of secondary benzathine penicillin prophylaxis, children with rheumatic fever have a high risk of Sydenham's chorea recurrence. Expand