REVIEW: Small Bowel Review: Normal Physiology, Part 2

  title={REVIEW: Small Bowel Review: Normal Physiology, Part 2},
  author={Alan B. R. Thomson and Laurie A. Drozdowski and Claudiu Iordache and Ben K.A. Thomson and S{\'e}verine Vermeire and Michael Tom Clandinin and Gary Wild},
  journal={Digestive Diseases and Sciences},
4 Citations
Ultrasound imaging for assessing functions of the GI tract
The main findings show the use of ultrasound to study esophageal motility, measure volume and contractility of the stomach, assess Motility, wall thickness, and perfusion of the small bowel, and evaluate wall vascularization and diameters of the large bowel. Expand
Human Intestinal Enteroids With Inducible Neurogenin-3 Expression as a Novel Model of Gut Hormone Secretion
Combining HIEs and inducible-NGN3 expression is combined to establish a flexible in vitro model system for functional studies of EECs in enteroids and advance the molecular and physiological investigation of E ECs. Expand
Motility Disorders of the Stomach and Small Intestine
Gastrointestinal dysmotility represents a severe constellation of symptoms resulting from malfunction of the stomach, small intestine, or large intestine, which range from diabetes to Parkinson’s to more exotic myopathies, although idiopathy remains the most commonly cited cause. Expand
Implication of gliadin toxicity on actin integrity and subsequent protein trafficking in vitro
Celiac disease (CD) is a chronic inflammation of the small intestine due to ingestion of gluten in genetically predisposed individuals (HLA-DQ2/DQ8). While there has been great progress in someExpand


Changes in Cell Proliferation and Differentiation of Adult Rat Small Intestine Epithelium After Adrenalectomy
Investigation of the effects of 10-day bilateral adrenalectomy on morphometry, proliferation, and apoptosis in 3-month-old Sprague–Dawley rats points to an important role of adrenals and glucocorticoids in the trophic status of the adult small intestinal mucosa. Expand
EGF and TGF-β1 Gene Expression in Chronically Rejecting Small Bowel Transplants
Reduced preproEGF and preserved TGF-β1 gene expression inchronically rejecting small bowel transplants are demonstrated in chronic rejection of DA isografts. Expand
Impaired Gut Contractility Following Hemorrhagic Shock is Accompanied by IL-6 and G-CSF Production and Neutrophil Infiltration
Whether or not HS initiates an inflammatory response that includes production of cytokines, specifically G-CSF and interleukin-6 (IL-6), and recruitment of leukocytes within the intestinal muscularis which contribute to impaired muscle contractility is examined. Expand
Intestinointestinal Inhibitory Reflexes
In conclusion, intraluminal distension of the jejunum severely impairs jejunal slow waves and the slow waves on both sides of distension become less coupled, less regular, and are of lower amplitude. Expand
Postprandial Response of Jejunal Slow Waves and Mediation via Cholinergic Mechanism
The postprandial response of the jejunal slow waves after a solid meal presents as an increase of the frequency of slow waves and the number of the spikebursts which can be abolished by atropine, and the postpr andial response is aneural reflex dominantly mediated via vagal cholinergicnerves. Expand
Short-Chain Fatty Acids Induce Cytoskeletal and Extracellular Protein Modifications Associated with Modulation of Proliferation on Primary Culture of Rat Intestinal Smooth Muscle Cells
Assessment of the effect of different short-chain fatty acids on ileal and colonic smooth muscle cells in primary culture and on A7R5 line suggested butyrate, which is produced by dietary fiber fermentation, may affect intestinal muscles by directly acting at the molecular level on myocytes. Expand
Tachykinins Stimulate Release of Peptide Hormones (Glucagon-Like Peptide-1) and Paracrine (Somatostatin) and Neurotransmitter (Vasoactive Intestinal Polypeptide) from Porcine Ileum Through NK-1 Receptors
It is concluded that tachykinins potently stimulate the release of GLP-1, somatostatin, and VIP in the porcine ileum viaNK-1 receptors and is partly mediated via cholinergic neurons. Expand
Transport and Metabolic Characterization of Caco-2 Cells Expressing CYP3A4 and CYP3A4 Plus Oxidoreductase
The monolayers of newly transfected Caco-2 cells (CYP3A4 + OR) have a significantly increased level of CYP3A 4 activities compared to untransfected cells, and also have desirable morphological and transport characteristics that are similar toUntransfecting cells. Expand
A silencer inhibitor confers specific expression of intestinal trefoil factor in gobletlike cell lines.
  • D. Iwakiri, D. Podolsky
  • Biology, Medicine
  • American journal of physiology. Gastrointestinal and liver physiology
  • 2001
It is concluded that goblet cell-specific transcription of ITF in vivo depends on a regulatory element designated GCSI, which enables human and murine gobleT cell-like cell lines to override the silencing effect of more proximal elements. Expand
Akt/PKB Activity Is Required for Ha-Ras-mediated Transformation of Intestinal Epithelial Cells*
It is demonstrated that inducible expression of oncogenic Ha-Ras results in activation of PKB/Akt in rat intestinal epithelial cells (RIE-iHa-RAs), which was blocked by treatment with inhibitors of PI3K activity. Expand