REVIEW: Nonalcoholic steatohepatitis

@article{Ludwig1997REVIEWNS,
  title={REVIEW: Nonalcoholic steatohepatitis},
  author={Jurgen Ludwig and Douglas B. McGill and Keith D. Lindor},
  journal={Journal of Gastroenterology and Hepatology},
  year={1997},
  volume={12}
}
Nonalcoholic steatohepatitis (NASH) is a reasonably well‐defined clinicopathological entity; it has been reported more commonly in women than in men or children of both sexes and it appears to be most closely associated with obesity, diabetes mellitus and related abnormalities, such as hyperlipidaemia and hyperglycaemia. However, the association with female gender, obesity and diabetes may not be as close as suggested by the literature and an underlying condition cannot be discerned in all… 

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References

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Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease.

Findings in 20 patients with nonalcoholic steatohepatitis of unknown cause found the patients were moderately obese, and many had obesity-associated diseases, such as diabetes mellitus and cholelithiasis.

The natural history of nonalcoholic fatty liver: A follow‐up study

In the absence of preexisting fibrosis or steatohepatitis, fatty liver of nonalcohol‐induced origin is an extremely benign condition.

The natural history of nonalcoholic steatohepatitis: A follow‐up study of forty‐two patients for up to 21 years

In individual patients, poorly controlled diabetes and rapid weight loss preceded the onset of steatohepatitis, and in the patients with extensive fibrosis the the liver disease evolved from one of active inflammation to one of inactive cirrhosis without fat or inflammation.

Nonalcoholic Fatty Hepatitis: An Important Clinical Condition

The roles of alcohol, obesity and type II diabetes are stressed where inhibition of fatty acid oxidation by the liver is the basic defect in metabolism leading to fatty change, balloon degeneration and Mallory body formation.

Fatty liver hepatitis (steatohepatitis) and obesity: An autopsy study with analysis of risk factors

Statohepatitis (fatty liver hepatitis), histologically identical to alcoholic disease, occurs in some obese patients after jejunoileal bypass, and incidence of steatosis and steatohePatitis correlated with the degree of obesity.

Nonalcoholic steatohepatitis in obesity: a reversible condition.

Nonalcoholic steatohepatitis is a rare complication of obesity with laboratory and histological features indistinguishable from alcoholic hepatitis and all responded with normalization of the biochemical and/or histological changes after modest weight reduction.

Ursodeoxycholic acid or clofibrate in the treatment of non‐alcohol‐induced steatohepatitis: A pilot study

Treatment of NASH with UDCA for 12 months resulted in significant improvement in alkaline phosphatase, ALT, GGT, and hepatic steatosis, but despite the known lipid‐lowering effects of clofibrate, it did not appear to be of clinical benefit in the treatment ofNASH in this 1‐year pilot study.
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