REVERSAL OF SERUM FUNGISTASIS BY ADDITION OF IRON.

@article{Caroline1964REVERSALOS,
  title={REVERSAL OF SERUM FUNGISTASIS BY ADDITION OF IRON.},
  author={Leona Caroline and Claire L. Taschdjian and Philip J. Kozinn and Arthur L. Schade},
  journal={The Journal of investigative dermatology},
  year={1964},
  volume={42},
  pages={
          415-9
        }
}
This paper deals with the role of the unsaturated iron-binding capacity of serum in its growth inhibitory action on Candida albicans. The fungistatic power of normal human serum has been described and studied by many investigators (1, 2, 3, 4, 5). Roth and coworkers showed that 10% to 20% of serum added to nutrient medium was sufficient to inhibit growth of Candida albicans. This inhibition could not be overcome by addition of various carbon and nitrogen sources (6, 7). 
Effect of pH and iron concentration on growth of Candida albicans in human serum.
TLDR
The growth-promoting capacity of human serum can be made commensurate with that of Sabouraud's broth by lowering the pH to 6.3 or by adding iron in excess of the total capacity to bind iron.
Antifungal activity of transferrin.
Inhibitory effects of transferrin on fungal growth were successfully estimated by measuring fungal ATP content. By this method, it was demonstrated that both human and rabbit transferrin possessed
Inhibition of growth of Candida albicans by iron-unsaturated lactoferrin: relation to host-defense mechanisms in chronic mucocutaneous candidiasis.
Since iron-binding proteins in serum and external secretions inhibit growth of certain microorganisms, the effect of lactoferrin on growth of Candida albicans was determined. The iron-unsaturated
The relationship of transferrin and iron to serum inhibition of Candida albicans.
TLDR
Serum from agammaglobulinemic patients has both a higher level of heat stable bacteriostatic activity against Bacillus subtilis and an increased unsaturated iron binding capacity (UIBC) compared to normal serum, which suggested that the increased levels of unsaturated transferrin may represent a compensatory defense mechanism in the agamaglOBulinemic host.
Production of a hemolytic factor by Candida albicans
TLDR
It is concluded that C. albicans expresses a hemolytic factor which allows it to acquire iron from host erythrocytes, and this factor can restore the transferrin-inhibited growth of C.Albicans.
Inhibition of catalase activity of Candida albicans by serum.
TLDR
The response of C. albicans to FeCl3 in serum-containing media indicates that the mycelial form may have a metabolism requiring iron for continued growth, and indicates how initiation of widespread candidiasis is prevented in a “normal” individual.
Fungistatic mechanism of human transferrin for Rhizopus oryzae and Trichophyton mentagrophytes: alternative to simple iron deprivation
TLDR
The results suggest that the fungistatic activity of TF for R. oryzae and T. mentagrophytes may not be attributable to simple iron deprivation and raise the possibility of a requirement for a direct interaction.
In Vitro Inhibition of Candidal Growth by Human Serum
TLDR
A serum factor lethal for Candida albicans which appeared to differ from Roth's factor in respect to specificity and apparent physical characteristics was described, and both appeared to be distinct from classical serum antibody.
The in vitro interactions of candida albicans with nonspecific serum proteins
TLDR
Although opsonization and phagocytosis probably play a vital role in the in vivo defenses against invading Candida, the contribution of these other interactions to host resistance remain unknown.
An antifungal factor in human serum. I. Studies of Rhizopus rhizopodiformis.
TLDR
The inhibitory effect was decreased in sera from patients with ketoacidotic diabetes, chronic leukemia and cirrhosis and dialysis of normal serum against saline removed inhibition in high serum concentrations.
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Communications relative to membership In the Association and to all matters of business of the Association should be Communications relative to articles offered for publication addressed to the Administrative Secretary, AAAS, 1515 Masshould be addressed to Editor, 15 15 Massachusetts Avenue, sachusetts Avenue, N. C.W.
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