REVERSAL OF NEUROMUSCULAR EFFECTS OF ADENOSINE BY SPECIFIC ADENOSINE A1-RECEPTOR ANTAGONIST IN LIVE RATS

@article{Nitahara2005REVERSALON,
  title={REVERSAL OF NEUROMUSCULAR EFFECTS OF ADENOSINE BY SPECIFIC ADENOSINE A1-RECEPTOR ANTAGONIST IN LIVE RATS},
  author={Keiichi Nitahara and Elek Sylvester Vizi and Shinjiro Shono and Mari Iihoshi and Hideyuki Higuchi and Kazuo Higa},
  journal={International Journal of Neuroscience},
  year={2005},
  volume={115},
  pages={405 - 410}
}
Intravenous adenosine in-vivo was shown to potentiate the effects of non-depolarizing neuromuscular blocking agents. This study aimed to determine whether adenosine A1-receptors mediated this potentiation. The authors investigated the effects of intravenous adenosine, N6-cyclopentyladenosine, specific A1-receptor agonist, and 8-cyclopentyl-1,3-dipropylxanthine, specific A1-receptor antagonist, on neuromuscular block by vecuronium, in in-vivo rat sciatic nervetibialis anterior preparations. In… Expand
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