REV7 counteracts DNA double-strand break resection and affects PARP inhibition

  title={REV7 counteracts DNA double-strand break resection and affects PARP inhibition},
  author={Guotai Xu and J Ross Chapman and Inger Brandsma and Jingsong Yuan and Martin Mistr{\'i}k and Peter Bouwman and Jirina Bartkova and Ewa Gogola and Dani{\"e}l O. Warmerdam and Marco Barazas and Janneke E. Jaspers and Kenji Watanabe and Mark Pieterse and Ariena Kersbergen and Wendy M P J Sol and Patrick H. N. Celie and Philip C. Schouten and B. C. van den Broek and Ahmed Salman and Marja Nieuwland and Iris de Rink and Jorma J. de Ronde and Kees Jalink and Simon J. Boulton and Junjie Chen and Dik C. van Gent and Jiri Bartek and Jos Jonkers and Piet Borst and Sven Rottenberg},
Error-free repair of DNA double-strand breaks (DSBs) is achieved by homologous recombination (HR), and BRCA1 is an important factor for this repair pathway. In the absence of BRCA1-mediated HR, the administration of PARP inhibitors induces synthetic lethality of tumour cells of patients with breast or ovarian cancers. Despite the benefit of this tailored therapy, drug resistance can occur by HR restoration. Genetic reversion of BRCA1-inactivating mutations can be the underlying mechanism of… CONTINUE READING
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