REV3, a Saccharomyces cerevisiae gene whose function is required for induced mutagenesis, is predicted to encode a nonessential DNA polymerase.

@article{Morrison1989REV3AS,
  title={REV3, a Saccharomyces cerevisiae gene whose function is required for induced mutagenesis, is predicted to encode a nonessential DNA polymerase.},
  author={Avril Morrison and Roshan B. Christensen and James Alley and Albert K. Beck and E G Bernstine and Jeffrey F. Lemontt and Christopher W. Lawrence},
  journal={Journal of bacteriology},
  year={1989},
  volume={171 10},
  pages={5659-67}
}
We have cloned the REV3 gene of Saccharomyces cerevisiae by complementation of the rev3 defect in UV-induced mutagenesis. The nucleotide sequence of this gene encodes a predicted protein of Mr 172,956 showing significant sequence similarity to Epstein-Barr virus DNA polymerase and to other members of a class of DNA polymerases including human DNA polymerase alpha and yeast DNA polymerase I. REV3 protein shows less sequence identity, and presumably a more distant evolutionary relationship, to… CONTINUE READING

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