RETRACTED ARTICLE: MicroRNA-144 mediates metabolic shift in ovarian cancer cells by directly targeting Glut1

@article{Fan2015RETRACTEDAM,
  title={RETRACTED ARTICLE: MicroRNA-144 mediates metabolic shift in ovarian cancer cells by directly targeting Glut1},
  author={Jia-Ying Fan and Yan Li Yang and Jing-Ying Xie and Yan-Ling Lu and Kun Shi and Yan-Qing Huang},
  journal={Tumor Biology},
  year={2015},
  volume={37},
  pages={6855-6860}
}
Warburg effect is characterized by an increased utilization of glucose via glycolysis in cancer cells, even when enough oxygen is present to properly respire. Recent studies demonstrate that deregulation of microRNAs contributes to the Warburg effect. In the present study, we show that miR-144 is downregulated while glucose transporter 1 (Glut1) is upregulated in ovarian cancers. In vitro studies further showed that miR-144 inhibits Glut1 expression through targeting its 3′-untranslated region… CONTINUE READING