RETRACTED: Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children

@article{Wakefield1998RETRACTEDIH,
  title={RETRACTED: Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children},
  author={A. J. Wakefield and S. H. Murch and Andrew Anthony and John D. C. Linnell and DM Casson and Mohsin K Malik and Mark Berelowitz and A. P. Dhillon and Ma Thomson and Peter Harvey and A Valentine and Selina Davies and J. A. Walker-smith},
  journal={The Lancet},
  year={1998},
  volume={351},
  pages={637-641}
}
BACKGROUND We investigated a consecutive series of children with chronic enterocolitis and regressive developmental disorder. [...] Key Method Children underwent gastroenterological, neurological, and developmental assessment and review of developmental records. Ileocolonoscopy and biopsy sampling, magnetic-resonance imaging (MRI), electroencephalography (EEG), and lumbar puncture were done under sedation. Barium follow-through radiography was done where possible.Expand
Enterocolitis in children with developmental disorders
TLDR
A new variant of inflammatory bowel disease is present in this group of children with developmental disorders, and scores of frequency and severity of inflammation were significantly greater in both affected children and those with UC, compared with controls. Expand
The significance of ileo-colonic lymphoid nodular hyperplasia in children with autistic spectrum disorder
TLDR
Ileo-colonic LNH is a characteristic pathological finding in children with ASD and gastrointestinal symptoms, and is associated with mucosal inflammation. Expand
Enterocolitis, autism and measles virus
TLDR
Intestinal permeability, measured by urinary excretion of inert sugars after oral dosing—a non-invasive marker of epithelial integrity—is elevated in some children with autism, even in the absence of symptoms. Expand
Colonic lymphoid nodular hyperplasia in children: relationship to food hypersensitivity.
  • G. Iacono, A. Ravelli, +6 authors A. Carroccio
  • Medicine
  • Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • 2007
TLDR
The presence of LNH in the colon and/or terminal ileum is a frequent finding in symptomatic children undergoing colonoscopy and unless associated with other specific endoscopic or histologic lesions, LNH is related to a condition of delayed-type food hypersensitivity. Expand
The Clinical Presentation and Outcome of Infants with Nodular Lymphoid Hyperplasia: Experience with 34 Cases from Southern Iran
TLDR
Evaluated the clinical presentation and outcome of infants with fresh rectal bleeding and final diagnosis of Nodular lymphoid hyperplasia, a relatively uncommon, but potentially important problem in early infancy. Expand
Nodular lymphoid hyperplasia: A marker of low-grade inflammation in irritable bowel syndrome?
TLDR
About 1/3 of patients with IBS-type symptoms or suspected IBD presented diffuse colonic NLH, which could be a marker of low-grade inflammation in a conspicuous subset of IBS patients. Expand
Colonic CD8 and gamma delta T-cell infiltration with epithelial damage in children with autism.
TLDR
Immunohistochemistry confirms a distinct lymphocytic colitis in autistic spectrum disorders in which the epithelium appears particularly affected, consistent with increasing evidence for gut epithelial dysfunction in autism. Expand
Retraction of an interpretation
TLDR
Ten of the 12 original authors of the Early Report “Ileal-lymphoidnodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children”, published in The Lancet in 1998 are considering together formally retract the interpretation placed upon these findings in the paper. Expand
Lymphoid hyperplasia of the colon and its association with underlying allergic airway diseases
TLDR
The results indicate that lymphoid hyperplasia in the large intestine may be associated with allergic airway diseases rather than with food allergies; thus, its presence may be useful to detect patients with underlying airway hyperreactivity. Expand
Measles, mumps, and rubella vaccination and bowel problems or developmental regression in children with autism: population study
TLDR
Findings provide no support for an MMR associated “new variant” form of autism with developmental regression and bowel problems, and further evidence against involvement of MMR vaccine in the initiation of autism. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 43 REFERENCES
Pathogenesis of aphthoid ulcers in Crohn's disease: correlative findings by magnifying colonoscopy, electron microscopy, and immunohistochemistry.
TLDR
The red halo appearance surrounding lymphoid follicles seems to precede visible aphthoid ulcers and suggests that ulcerations in Crohn's disease originate from FAE, possibly related to its physiological role as a portal of entry for potentially pathogenic agents. Expand
Food allergy and infantile autism.
TLDR
The results lead us to hypothesise a relationship between food allergy and infantile autism as has already been suggested for other disturbances of the central nervous system. Expand
Abnormal intestinal permeability in children with autism
TLDR
It is speculated that an altered intestinal permeability could represent a possible mechanism for the increased passage through the gut mucosa of peptides derived from foods with subsequent behavioural abnormalities. Expand
Dialysable lymphocyte extract (DLyE) in infantile onset autism: A pilot study
TLDR
After cessation of TF therapy, 5 in the autistic group and 3 of the pseudo-autistic group regressed, but they did not drop as low as baseline levels. Expand
Perinatal measles infection and subsequent Crohn's disease
TLDR
The hypothesis that measles is related to Crohn's disease and that the perinatal period is a time of vulnerability is strengthened. Expand
Is measles vaccination a risk factor for inflammatory bowel disease?
TLDR
It is suggested that measles virus may play a part in the development not only of Crohn's disease but also of ulcerative colitis. Expand
Mental retardation, megaloblastic anaemia, methylmalonic aciduria and abnormal homocysteine metabolism due to an error in vitamin B12 metabolism.
TLDR
A child with retarded physical and mental development, recurrent megaloblastic anaemia, methylmalonic aciduria and abnormal homocysteine metabolism resulting from an inborn error in the metabolism of cobalamins died at the age of 7 years. Expand
Autistic spectrum disorders
Autism seems to be on the increase. This at least is the feeling of many professionals in the field of child development in Britain, who believe that in recent years they have been seeing moreExpand
Disruption of sulphated glycosaminoglycans in intestinal inflammation
TLDR
It is suggested that inflammatory disruption of vascular and connective tissue GAGs may be an important pathogenetic mechanism, contributing to the leakage of protein and fluid, thrombosis, and tissue remodelling seen in inflammatory bowel disease. Expand
The autistic spectrum
  • L. Wing
  • Medicine, Psychology
  • The Lancet
  • 1997
TLDR
A simple system of subgrouping based solely on a description of the type of social impairment will be used, which avoids the confusion inherent in trying to identify the named syndromes. Expand
...
1
2
3
4
5
...