RETRACTED: Biomarkers of alcoholism: an updated review

  title={RETRACTED: Biomarkers of alcoholism: an updated review},
  author={S. K. Das and L. Dhanya and Damodaran M Vasudevan},
  journal={Scandinavian Journal of Clinical and Laboratory Investigation},
  pages={81 - 92}
Development of Biomarkers for Alcoholism and Polysubstance Abuse
The recent studies of addiction reviewed in this chapter provide a basis of potential biological markers in future medicine and some molecules may have potentials to be useful biomarkers for the disorder.
Genetic Markers Related to Alcohol Use and Abuse
Sustained drug delivery strategies for treatment of common substance use disorders: Promises and challenges.
  • A. Tijani, Jivesh Garg, A. Puri
  • Medicine
    Journal of controlled release : official journal of the Controlled Release Society
  • 2022
Melatonin and alcohol-related disorders
This review concerns the current knowledge of melatonin and alcohol-related disorders and shows alcohol toxicity is modulated by the melatonin (Mel) circadian rhythm, which exhibits antioxidant properties and may be useful in the prevention of oxidative stress reactions known to be responsible for alcohol- related diseases.
Future prospects for biomarkers of alcohol consumption and alcohol-induced disorders.
It is recommended that NIAAA consider taking a leadership role in organizing investigators in the field and providing a common set of clinical specimens for biomarker validation studies, and the alcohol research field must reach a competitive level of rigor and organization.
Alcohol Biomarkers
The Role of Alcohol Consumption on Physical Functioning in Middle-aged and Older Adults in Central and Eastern Europe
The excess risk of physical limitations in non-drinkers at baseline was partly explained by ‘sick quitters’, and the apparently protective effect of heavier drinking was partly due to less healthy former heavy drinkers moving to lower drinking categories.
5-HIAA as a Potential Biological Marker for Neurological and Psychiatric Disorders
Evolving of 5HIAA as a biomarker, could be more delicate and enhanced strategy for monitoring these disorders like Alzheimer’s disease, schizophrenia, depression and so on.
Circuits and Molecular Mechanisms
Because ethanol affects neural activity in some brain sites but is without effect in others, its actions are analyzed in terms of integrated connectivities in the functional circuitry of neuronal networks, which are of particular interest because of the cognitive interactions discussed in the manu- scripts contributing to this review.


Ethyl glucuronide: a biomarker to identify alcohol use by health professionals recovering from substance use disorders.
Ethyl glucuronide (EtG), a direct metabolite of alcohol, offers an extended window for assessment of drinking status (up to 5 days) and incorporation of EtG testing into alcohol abstinence monitoring can strengthen these programs.
Alcohol: its health and social impact in India.
The crucial need, from a public health perspective, is for regular means of coordination whereby prevention of alcohol-related problems is taken fully into account in policy decisions about alcohol control and regulation in the market for alcoholic beverages.
Prediction of alcohol-related harm by laboratory test results.
It is concluded that these readily available laboratory tests provide important prognostic information and should be an integral part of the assessment of persons with hazardous alcohol consumption.
Serum bilirubin subfractions in patients with alcohol abuse during detoxication.
The results suggest that mild cholestasis is common among alcohol-abusers without clinically evident liver disease and that these changes are reversible on abstention.
Biochemical and hematologic correlates of alcoholism and liver disease.
Utility of the quadratic discriminant approach was demonstrated when 83% alcoholic and 83% nonalcoholic liver disease cases were diagnosed correctly in a prospective manner, and use of aspartate aminotransferase to alanine aminotsferase ratios identified correctly 75% and 33% of patients, respectively.
Changes in amylase, hepatic enzymes and bilirubin in serum upon initiation of alcohol abstinence.
In patients with low activities initially, the S-pancreatic isoamylase activity increased during the observation period and thus, pathologically increased activities were recorded more often 9 days after alcohol withdrawal than on arrival at the hospital.
Immune Responses to Ethanol Metabolites and Cytokine Profiles Differentiate Alcoholics with or without Liver Disease
Alcoholic liver disease is associated with the generation of IgAs and IgGs against acetaldehyde-derived antigens and enhanced levels of both pro- and antiinflammatory cytokines, whereas elevated IgA, IL-6, and IL-10 characterize alcoholics without liver disease.
Alcoholic liver disease: proposed recommendations for the American College of Gastroenterology
This work developed practice guidelines for the management of alcoholic liver disease using the Medline Data Base from 1966–July 1997 and evaluated evidence using a hierarchical scale with randomized, controlled trials given the most importance.
Antibodies against acetaldehyde‐modified epitopes: an elevated IgA response in alcoholics
An enzyme‐linked immunosorbent assay (ELISA) is employed to assess the classes of immunoglobulin involved in this response, using plasma samples from 97 alcoholics with varying degrees of liver disease, 35 patients with non‐alcoholic liver disease and 33 control subjects, which suggests that the measurement of the IgA response to AcH‐modified epitopes may be a specific marker of ethanol abuse.
Erythrocyte aldehyde dehydrogenase activity in alcoholism.
The findings show that the decreased activity of erythrocyte aldehyde dehydrogenase which occurs in association with alcohol ingestion is not an inherent characteristic of alcoholism.