RETRACTED: An ATP-competitive inhibitor modulates the allosteric function of the HER3 pseudokinase.

  title={RETRACTED: An ATP-competitive inhibitor modulates the allosteric function of the HER3 pseudokinase.},
  author={P. J. Littlefield and Mark M. Moasser and Natalia Jura},
  journal={Chemistry & biology},
  volume={21 4},
Human epidermal growth factor receptor 3 (HER3) is a receptor tyrosine kinase that lacks catalytic activity but is essential for cellular homeostasis due to its ability to allosterically activate EGFR and HER2. Although catalytically inactive, HER3 binds ATP tightly, hinting at a possible role of the nucleotide-binding pocket in modulating HER3 function. We report a structure of the HER3 pseudokinase bound to the ATP-competitive inhibitor bosutinib. Previously solved structures show that… CONTINUE READING
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