RETRACTED: ATP Hydrolysis-Dependent Disassembly of the 26S Proteasome Is Part of the Catalytic Cycle

@article{Babbitt2005RETRACTEDAH,
  title={RETRACTED: ATP Hydrolysis-Dependent Disassembly of the 26S Proteasome Is Part of the Catalytic Cycle},
  author={Shalon E Babbitt and Alexi Kiss and Andrew E Deffenbaugh and Y Chang and Eric Bailly and Hediye Erdjument-Bromage and Paul Tempst and Tione Buranda and Larry A. Sklar and Jennifer Baumler and Edward P. Gogol and Dorota Skowyra},
  journal={Cell},
  year={2005},
  volume={121},
  pages={553-565}
}
ATP hydrolysis is required for degradation of polyubiquitinated proteins by the 26S proteasome but is thought to play no role in proteasomal stability during the catalytic cycle. In contrast to this view, we report that ATP hydrolysis triggers rapid dissociation of the 19S regulatory particles from immunopurified 26S complexes in a manner coincident with release of the bulk of proteasome-interacting proteins. Strikingly, this mechanism leads to quantitative disassembly of the 19S into… CONTINUE READING