RET signaling is required for survival and normal function of nonpeptidergic nociceptors.

@article{Golden2010RETSI,
  title={RET signaling is required for survival and normal function of nonpeptidergic nociceptors.},
  author={Judith P. Golden and Masato Hoshi and Mohammed A. Nassar and Hideki Enomoto and John N Wood and Jeffrey D. Milbrandt and Robert W Gereau and Eugene Malcolm Johnson and Sanjay Jain},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2010},
  volume={30 11},
  pages={3983-94}
}
Small unmyelinated sensory neurons classified as nociceptors are divided into two subpopulations based on phenotypic differences, including expression of neurotrophic factor receptors. Approximately half of unmyelinated nociceptors express the NGF receptor TrkA, and half express the GDNF family ligand (GFL) receptor Ret. The function of NGF/TrkA signaling… CONTINUE READING