RET signaling does not modulate MPTP toxicity but is required for regeneration of dopaminergic axon terminals.

Abstract

Activation of the RET (rearranged during transfection) receptor by glial cell-line-derived neurotrophic factor (GDNF) has been identified as an important differentiation and survival factor for dopaminergic neurons of the midbrain in preclinical experiments. These encouraging results have led to clinical trials of GDNF in patients with Parkinson's disease… (More)

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