RET proto-oncogene mutations are restricted to codon 618 in Cypriot families with multiple endocrine neoplasia 2.

@article{Neocleous2011RETPM,
  title={RET proto-oncogene mutations are restricted to codon 618 in Cypriot families with multiple endocrine neoplasia 2.},
  author={Vassos Neocleous and Nicos Skordis and George Portides and Elisavet Efstathiou and Constandina Costi and Nikolaos Ioannou and Marios C Pantzaris and Violetta Anastasiadou and Constantinos Deltas and Leonidas A. Phylactou},
  journal={Journal of endocrinological investigation},
  year={2011},
  volume={34 10},
  pages={764-9}
}
BACKGROUND RET germline mutations predispose to the development of inherited cancer syndrome multiple endocrine neoplasia type 2 (MEN2). Several variants of the RET proto-oncogene including G691S and S904S have been suggested to act as genetic modifiers at the age of onset ofMEN2. AIM The aim of this study is to characterize clinically and molecularly 7 Cypriot patients with familial medullary thyroid carcinoma (FMTC) and 1 with MEN2A and also to determine the allelic frequencies of the RET… CONTINUE READING