RET oncogene activation in papillary thyroid carcinoma.

  title={RET oncogene activation in papillary thyroid carcinoma.},
  author={G. Tallini and Sylvia L Asa},
  journal={Advances in anatomic pathology},
  volume={8 6},
The RET proto-oncogene encodes a cell membrane tyrosine-kinase receptor protein whose ligands belong to the glial cell line-derived neurotrophic factor. RET functions as a multicompetent receptor complex that includes alphaGFRs and RET. Somatic rearrangements of RET designated as RET/PTC (from papillary thyroid carcinoma) were identified in papillary thyroid carcinoma before RET was recognized as the susceptibility gene for MEN2. There are now at least at least 15 types of RET/PTC… CONTINUE READING
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