RET fusion gene: translation to personalized lung cancer therapy.

  title={RET fusion gene: translation to personalized lung cancer therapy.},
  author={Takashi Kohno and Koji Tsuta and Katsuya Tsuchihara and Takashi Nakaoku and Kiyotaka Yoh and Koichi Goto},
  journal={Cancer science},
  volume={104 11},
Development of lung adenocarcinoma (LADC), the most frequent histological type of lung cancer, depends in many cases on the activation of "driver" oncogenes such as KRAS, epidermal growth factor receptor (EGFR), and anaplastic lymphoma kinase (ALK). Inhibitors that target the EGFR and ALK tyrosine kinases show therapeutic effects against LADCs containing EGFR gene mutations and ALK gene fusions, respectively. Recently, we and others identified the RET fusion gene as a new targetable driver gene… CONTINUE READING
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