RET/PTC3 Rearrangement in Papillary Thyroid Carcinoma: Possible Marker of Tumor Progression.

@article{Jargin2017RETPTC3RI,
  title={RET/PTC3 Rearrangement in Papillary Thyroid Carcinoma: Possible Marker of Tumor Progression.},
  author={Sergei V. Jargin},
  journal={Annals of surgery},
  year={2017},
  volume={266 6},
  pages={
          e120-e121
        }
}
  • S. Jargin
  • Published 1 December 2017
  • Medicine
  • Annals of surgery
2. J Clin Endocrinol Metab. 2016 Nov 16:jc20162555. [Epub ahead of print] Germline polymorphisms of the VEGF-pathway predict recurrence in non-advanced differentiated thyroid cancer. Marotta V(1), Sciammarella C(1), Capasso M(2), Testori A(2), Pivonello C(3), Chiofalo MG(4), Gambardella C(5), Grasso M(6), Antonino A(7), Annunziata A(8), Macchia PE(3), Pivonello R(3), Santini L(5), Botti G(8), Losito S(8), Pezzullo L(4), Colao A(3), Faggiano A(4). Author information: (1)1 IOS & COLEMAN Srl… 
2 Citations
Chromosomal Rearrangements of RET/PTC in Post-Chernobyl Thyroid Cancer
TLDR
In conclusion, RET rearrangements, especially RET/PTC3, were correlated with the tumor progression and if the hypothesis defended here is correct, a low prevalence of RET/ PTC3 among sporadic TC is circumstantial evidence of efficient cancer diagnosis and early detection.
Mutations of genes including DNMT3A detected by next-generation sequencing in thyroid cancer
TLDR
A retrospective analysis of the formalin-fixed paraffin-embedded tumor samples from 50 patients who mainly displayed aggressive thyroid cancer reported that mutation in DNMT3A gene was significantly enriched in patients with PDTC or ATC.

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The results indicate that RET/PTC3 gene rearrangements are the most prevalent form of rearrangement in PTCs of Chennai population, and no statistically significant difference observed between positive and negative mutations of RET/ PTC3 mRNA expression with clinic pathological parameters.
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