RET/PTC3 Rearrangement in Papillary Thyroid Carcinoma: Possible Marker of Tumor Progression.

  title={RET/PTC3 Rearrangement in Papillary Thyroid Carcinoma: Possible Marker of Tumor Progression.},
  author={Sergei V. Jargin},
  journal={Annals of surgery},
  volume={266 6},
  • S. Jargin
  • Published 1 December 2017
  • Medicine
  • Annals of surgery
2. J Clin Endocrinol Metab. 2016 Nov 16:jc20162555. [Epub ahead of print] Germline polymorphisms of the VEGF-pathway predict recurrence in non-advanced differentiated thyroid cancer. Marotta V(1), Sciammarella C(1), Capasso M(2), Testori A(2), Pivonello C(3), Chiofalo MG(4), Gambardella C(5), Grasso M(6), Antonino A(7), Annunziata A(8), Macchia PE(3), Pivonello R(3), Santini L(5), Botti G(8), Losito S(8), Pezzullo L(4), Colao A(3), Faggiano A(4). Author information: (1)1 IOS & COLEMAN Srl… 
2 Citations
Chromosomal Rearrangements of RET/PTC in Post-Chernobyl Thyroid Cancer
In conclusion, RET rearrangements, especially RET/PTC3, were correlated with the tumor progression and if the hypothesis defended here is correct, a low prevalence of RET/ PTC3 among sporadic TC is circumstantial evidence of efficient cancer diagnosis and early detection.
Mutations of genes including DNMT3A detected by next-generation sequencing in thyroid cancer
A retrospective analysis of the formalin-fixed paraffin-embedded tumor samples from 50 patients who mainly displayed aggressive thyroid cancer reported that mutation in DNMT3A gene was significantly enriched in patients with PDTC or ATC.


Tumor genotype determines phenotype and disease-related outcomes in thyroid cancer: a study of 1510 patients.
In this large study of prospective mutation testing in unselected patients with TC, molecular signature was associated with distinctive phenotypes including cancers, with higher risks of both distant metastasis and early recurrence.
ENDOCRINE TUMOURS: Genetic predictors of thyroid cancer outcome.
This review addresses only genetic alterations detected by molecular methods in surgically resected specimens, thus ruling out immunohistochemistry and (F)ISH, despite their crucial relevance as topographically oriented methods.
Prevalence of RET/PTC1 and RET/PTC3 gene rearrangements in Chennai population and its correlation with clinical parameters
The results indicate that RET/PTC3 gene rearrangements are the most prevalent form of rearrangement in PTCs of Chennai population, and no statistically significant difference observed between positive and negative mutations of RET/ PTC3 mRNA expression with clinic pathological parameters.
Pattern of radiation-induced RET and NTRK1 rearrangements in 191 post-chernobyl papillary thyroid carcinomas: biological, phenotypic, and clinical implications.
The genotype/phenotype evaluation of post-Chernobyl PTCs reveals a characteristic spectrum of gene rearrangements that lead to typical phenotypes with important biological and clinical implications.
Molecular diagnostics of thyroid tumors.
  • Y. Nikiforov
  • Medicine, Biology
    Archives of pathology & laboratory medicine
  • 2011
The use of RAS, RET/PTC, and PAX8/PPAR γ mutations is expected to improve significantly the accuracy of cancer diagnosis in thyroid nodules and allow more individualized surgical and postsurgical management of patients with thyroid cancer.
ret/PTC1 and ret/PTC3 in thyroid tumors from Chernobyl liquidators: comparison with sporadic tumors from Ukrainian and French patients.
The finding that liquidators showed a high prevalence of ret/PTC3 suggests that irradiation had the same effect regardless of age, and the possibility of genetic susceptibility or low-level exposure to radiation in that group cannot be excluded.
Intracellular Signal Transduction and Modification of the Tumor Microenvironment Induced by RET/PTCs in Papillary Thyroid Carcinoma
The mechanisms involved in RET/PTC-induced thyroid cell transformation are examined and its function as a dominant oncogene, on the activated signal transduction pathways and on the induced gene expression modifications are summarized.
Chernobyl-Related Cancer and Precancerous Lesions: Incidence Increase Vs. Late Diagnostics
  • S. Jargin
  • Medicine
    Dose-response : a publication of International Hormesis Society
  • 2014
The screening-effect, false-positivity and registration of non-exposed patients as Chernobyl victims has obviously contributed to the registered incidence increase of malignancy.
Radiation carcinogenesis: lessons from Chernobyl
The type and molecular pathology of the thyroid tumors is changing with increasing latency, long latency tumors in other organs could occur in the future, and more information is needed on germline mutations conferring susceptibility to radiation-induced PTCs, particularly DNA repair genes.
RET/PTC Translocations and Clinico-Pathological Features in Human Papillary Thyroid Carcinoma
The RET protein and mRNA expression level did not show any correlation with the outcome of patients with PTC and no correlation between RET/PTC rearrangements and the expression level of the thyroid differentiation genes was observed, which makes this procedure not applicable at routine level, at least for the moment.