RET/PTC rearrangement in thyroid tumors

@article{Nikiforov2002RETPTCRI,
  title={RET/PTC rearrangement in thyroid tumors},
  author={Yuri E. Nikiforov},
  journal={Endocrine Pathology},
  year={2002},
  volume={13},
  pages={3-16}
}
Rearrangement of the RET gene, also known as RET/PTC rearrangement, is the most common genetic alteration identified to date in thyroid papillary carcinomas. The prevalence of RET/PTC in papillary carcinomas shows significant geographic variation and is approx 35% in North America. RET/PTC is more common in tumors in children and young adults, and in papillary carcinomas associated with radiation exposure. There are at least 10 different types of RET/PTC, all resulting from the fusion of the… 
Papillary Thyroid Carcinoma and RET / PTC Oncogenes
TLDR
Rearrangement of the RET gene, also known as RET/PTC rearrangement, is the most common genetic alteration identified to date in thyroid papillary carcinomas and may well be a marker for radiation-induced carcinoma, particularly in children.
RET/PTC Translocations and Clinico-Pathological Features in Human Papillary Thyroid Carcinoma
TLDR
The RET protein and mRNA expression level did not show any correlation with the outcome of patients with PTC and no correlation between RET/PTC rearrangements and the expression level of the thyroid differentiation genes was observed, which makes this procedure not applicable at routine level, at least for the moment.
RET/PTC rearrangements arising from a small population of papillary thyroid carcinoma cells, possible candidate for passenger mutation
TLDR
The results suggested the possibility of RET/PTC as “passenger” abnormalities rather than “driver” oncogenic mutation during thyroid cancer progression, warranting further studies on mechanisms and implication of RET gene instability.
Ret/PTC activation does not influence clinical and pathological features of adult papillary thyroid carcinomas.
TLDR
Data indicate that RET rearrangements may not play any distinctive role in driving histotype development and cancer progression in these neoplasms, and weaken the possibility of using ret/PTC as a prognostic marker for papillary thyroid carcinomas.
RET/PTC Gene Rearrangements in Thyroid Carcinogenesis: Assessment and Clinico-Pathological Correlations
TLDR
Overall, this study advocates that RET/PTC3 rearrangement is a frequent event in the carcinogenesis of thyroid gland in Kashmiri population although a study with a larger sample size is needed to get a clear scenario.
Editorial : RET / PTC Rearrangement — A Link between Hashimoto ’ s Thyroiditis and Thyroid Cancer
TLDR
The conclusions on the association between Hashimoto’s thyroiditis and the occurrence of multiple tumors in most thyroid glands were met with substantial skepticism, but two studies provided some evidence suggesting that RET/PTC may be present in a subpopulation of cells in the thyroid glands affected by Hashimoto's thyroiditis.
Prevalence of RET/PTC1 and RET/PTC3 gene rearrangements in Chennai population and its correlation with clinical parameters
TLDR
The results indicate that RET/PTC3 gene rearrangements are the most prevalent form of rearrangement in PTCs of Chennai population, and no statistically significant difference observed between positive and negative mutations of RET/ PTC3 mRNA expression with clinic pathological parameters.
The RET oncogene in papillary thyroid carcinoma
TLDR
The authors review the current understanding of the clinicopathologic role of RET/PTC fusion proteins in PTC development and progression and the molecular mechanisms by which RET/ PTCs exert their oncogenic effects on the thyroid epithelium.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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