RESTORING FUNCTION AFTER SPINAL CORD INJURY

@article{Becker2003RESTORINGFA,
  title={RESTORING FUNCTION AFTER SPINAL CORD INJURY},
  author={Daniel Becker and Cristina L Sadowsky and John W. Mcdonald},
  journal={The Neurologist},
  year={2003},
  volume={9},
  pages={1-15}
}
BACKGROUND–By affecting young people during the most productive period of their lives, spinal cord injury (SCI) is a devastating problem for modern society. A decade ago, treating SCI seemed frustrating and hopeless because of the tremendous morbidity and mortality, life-shattering impact, and limited therapeutic options associated with the condition. Today, however, an understanding of the underlying pathophysiological mechanisms, the development of neuroprotective interventions, and progress… 
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98 Citations
Highly Influential Citations
4
Background Citations
30
Methods Citations
1

98 Citations

Citation Type

Citation Type

Approaches to repairing the damaged spinal cord: overview.
Spinal-cord injury
Cell targeted nanoparticle-based drug delivery systems for spinal cord injury regeneration
TLDR
This thesis explored the application of the developed CMCht/PAMAM dendrimer nanoparticles for neuroprotection of the injured spinal cord tissue, ultimately contributing to regeneration and repair.
Effect of microenvironment modulation on stem cell therapy for spinal cord injury pain
TLDR
Remyelination of demyelinated/dysmyelinated axons in the injured spinal cord could be an important repair therapy for SCI and one of the key elements for functional recovery and aberrant sprouting prevention after SCI.
Repairing the damaged spinal cord: from stem cells to activity-based restoration therapies.
TLDR
Current concepts of the pathophysiology, repair and restora on of func on in the damaged spinal cord are presented with an overlay of how neural stem cells, par cularly ES cells, fit into the picture as important scien fic tools that will translate into discoveries and rapid progress in neural repair.
69 – Spinal Cord Injury
Incomplete Spinal Cord Injury in Enugu, Nigeria: Epidemeology and Outcome
TLDR
The significant ASIA grade improvement of majority of the patients suggests good functional outcome of incomplete SCI treated conservatively at National Orthopedic Hospital Enugu, Nigeria, over a 5 year period.
Restoring walking after spinal cord injury
Effect of Gender on Recovery After Spinal Cord Injury
TLDR
The current review examines the experimental and clinical evidence for a gender bias in outcome following SCI and discusses issues that have made it difficult to conclusively answer this question.
Demyelination and remyelination after spinal cord injury.
TLDR
It is now recognized that, as well as promoting salutatory conduction along axons, oligodendroglia are important near-term clinical targets for restoring function after CNS injury, particularly spinal cord injury, and remyelination appears to be one of the most feasible restoration strategies.
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References

SHOWING 1-10 OF 180 REFERENCES
Therapeutic interventions following mammalian spinal cord injury.
TLDR
The pathological events that contribute to the poor regenerative capacity of the injured spinal Cord are discussed and experimental methods that are being used to both minimize tissue damage and promote the regrowth of injured spinal cord axons are described.
Late recovery following spinal cord injury. Case report and review of the literature.
TLDR
The primary novelty of this report is the demonstration that substantial recovery of function is possible in a patient with severe C-2 ASIA Grade A injury, long after the initial SCI.
Spinal-cord injury
The role and timing of decompression in acute spinal cord injury: what do we know? What should we do?
TLDR
A review of the current evidence available in the literature suggests that there is no standard of care regarding the role and timing of surgical decompression in acute spinal cord injury, and there is a strong rationale to undertake prospective, controlled trials to evaluate the role of decompression.
Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms.
TLDR
Evidence is presented to support the theory of secondary injury and the hypothesis that a key mechanism is posttraumatic ischemia with resultant infarction of the spinal cord and that it can be counteracted.
Recovery of motor function after spinal-cord injury--a randomized, placebo-controlled trial with GM-1 ganglioside.
TLDR
Evidence is provided that GM-1 enhances the recovery of neurologic function after one year in patients with spinal-cord injuries and that the increased recovery was attributable to initially paralyzed muscles that regained useful motor strength rather than to strengthening of paretic muscles.
Clinical Trials of Pharmacotherapy for Spinal Cord Injury
  • F. Geisler
  • Medicine
    Annals of the New York Academy of Sciences
  • 1998
TLDR
This study formed the basis for the currently ongoing larger placebo‐controlled multicentered study using Sygen® GM‐1 following acute spinal cord injury and is expected to present results in early 1998.
The effectiveness of surgery on the treatment of acute spinal cord injury and its relation to pharmacological treatment.
TLDR
The results suggest that either early surgery (< or = 25 hours after injury) or late surgery (> 200 hours) may be associated with increased neurological recovery, particularly motor function, but these results are equivocal.
▪ Spinal Cord Injury: Role of Steroid Therapy
TLDR
Even with the controversies and unresolved issues, the authors advocate initiation of intensive gluco‐corticosteroid therapy as soon as possible after acute spinal cord injury, and not beyond the first 8 hours.
Acute treatment of spinal cord injury
TLDR
The initial goal after resuscitation and evaluation is to assure adequate tissue oxygenation through blood pressure support and oxygen supplementation, which helps ensure maximal oxygen delivery to the injured spinal cord.
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