REST maintains self-renewal and pluripotency of embryonic stem cells

@article{Singh2008RESTMS,
  title={REST maintains self-renewal and pluripotency of embryonic stem cells},
  author={Sanjay K. Singh and Mohamedi N. Kagalwala and Jan V Parker-Thornburg and Henry Adams and Sadhan Majumder},
  journal={Nature},
  year={2008},
  volume={453},
  pages={223-227}
}
The neuronal repressor REST (RE1-silencing transcription factor; also called NRSF) is expressed at high levels in mouse embryonic stem (ES) cells, but its role in these cells is unclear. Here we show that REST maintains self-renewal and pluripotency in mouse ES cells through suppression of the microRNA miR-21. We found that, as with known self-renewal markers, the level of REST expression is much higher in self-renewing mouse ES cells than in differentiating mouse ES (embryoid body, EB) cells… CONTINUE READING
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lessons from REST

  • L. Ooi, Wood, I. C. Chromatin crosstalk in development, disease
  • Nature Rev. Genet. 8, 544–554
  • 2007