REST: A mammalian silencer protein that restricts sodium channel gene expression to neurons

@article{Chong1995RESTAM,
  title={REST: A mammalian silencer protein that restricts sodium channel gene expression to neurons},
  author={J. Chong and J. Tapia-Ram{\'i}rez and S. Kim and J. J. Toledo-Aral and Y. Zheng and M. Boutros and Y. Altshuller and M. Frohman and S. Kraner and G. Mandel},
  journal={Cell},
  year={1995},
  volume={80},
  pages={949-957}
}
  • J. Chong, J. Tapia-Ramírez, +7 authors G. Mandel
  • Published 1995
  • Biology, Medicine
  • Cell
  • Expression of the type II voltage-dependent sodium channel gene is restricted to neurons by a silencer element active in nonneuronal cells. We have cloned cDNA coding for a transcription factor (REST) that binds to this silencer element. Expression of a recombinant REST protein confers the ability to silence type II reporter genes in neuronal cell types lacking the native REST protein, whereas expression of a dominant negative form of REST in nonneuronal cells relieves silencing mediated by the… CONTINUE READING
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