RESPONSE SURFACE METHODOLOGY FOR OPTIMIZATION OF DICLOFENAC SODIUM ORODISPERSIBLE TABLETS ( ODTs )

Abstract

The aim of this study was to optimize 25 mg diclofenac sodium orodispersible tablets. For this it was used a Box Behnken experimental design to establish the relation between independent variables, such as, concentration of Pharmaburst 500 (X1), Avicel PH 102 (X2) and compression force (X3), and dependent variables: friability (Y1), disintegration time (Y2… (More)

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