RESIDUES 207, 216, AND 221 AND THE CATALYTIC ACTIVITY OF MGSTA1-1 AND MGSTA2-2 TOWARD BENZO[A]PYRENE-(7R,8S)-DIOL-(9S,10R)-EPOXIDE

@inproceedings{Gu2003RESIDUES22,
  title={RESIDUES 207, 216, AND 221 AND THE CATALYTIC ACTIVITY OF MGSTA1-1 AND MGSTA2-2 TOWARD BENZO[A]PYRENE-(7R,8S)-DIOL-(9S,10R)-EPOXIDE},
  author={Yijun Gu and Bing Xiao and Heather Wargo and Matthew H Bucher and Shivendra V Singh and Xinhua Ji},
  year={2003}
}
  • Yijun Gu, Bing Xiao, +3 authors Xinhua Ji
  • Published 2003
  • Chemistry
  • Murine class alpha glutathione S-transferase subunit types A2 (mGSTA2-2) and A1 (mGSTA1-1) have high catalytic efficiency for glutathione (GSH) conjugation of the ultimate carcinogenic metabolite of benzo[a]pyrene, (+)-anti-7,8-dihydroxy-9,10-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene, [(+)-anti-BPDE]. Only 10 residues differ between the sequences of mGSTA1-1 and 2-2. However, the catalytic efficiency of mGSTA1-1 for GSH conjugation of (+)-anti-BPDE is >3-fold higher as compared with mGSTA2-2. The… CONTINUE READING

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