REPLICATION PROTEIN A 32kDa SUBUNIT (RPA p32) BINDS THE SH2 DOMAIN OF STAT3 AND REGULATES ITS TRANSCRIPTIONAL ACTIVITY

@article{Kim2000REPLICATIONPA,
  title={REPLICATION PROTEIN A 32kDa SUBUNIT (RPA p32) BINDS THE SH2 DOMAIN OF STAT3 AND REGULATES ITS TRANSCRIPTIONAL ACTIVITY},
  author={J. Kim and D. Kim and J. Chung},
  journal={Cell Biology International},
  year={2000},
  volume={24}
}
STATs (signal transducers and activators of transcription) are transcription factors that contain SH2 domains and are activated by tyrosine phosphorylation in response to cytokines and growth factors. Replication protein A (RPA) is a heterotrimeric complex that consists of three subunits, p70, p32 and p11, and has important functions in DNA replication and metabolism. Here, we present evidence that the RPA p32 subunit binds specifically to the SH2 domain of STAT3 in a phosphotyrosine… Expand
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