REP-2, a Rab escort protein encoded by the choroideremia-like gene.

@article{Cremers1994REP2AR,
  title={REP-2, a Rab escort protein encoded by the choroideremia-like gene.},
  author={Frans P. M. Cremers and Sula A Armstrong and Miguel C. Seabra and Michael Scott Brown and Joseph L Goldstein},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 3},
  pages={2111-7}
}
Rab escort proteins (REPs) bind to newly synthesized Rab proteins and remain bound during and after the attachment of a geranylgeranyl (GG) group by the catalytic component of the Rab GG transferase. Transfer of the GG group is absolutely dependent on the participation of a REP. REP-1, the first characterized REP, is produced by a gene on the X chromosome that is defective in patients with choroideremia, a form of retinal degeneration. Cremers et al. (Cremers, F.P.M., Molloy, C. M., van de Pol… CONTINUE READING
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