REM sleep behavior disorder, as assessed by questionnaire, in G2019S LRRK2 mutation PD and carriers.


BACKGROUND Rapid eye movement sleep behavior disorder occurs with idiopathic Parkinson's disease (PD) and often precedes PD. Its frequency in LRRK2-PD and utility as a preclinical marker has not been established. METHODS One hundred forty-four idiopathic PD, 142 LRRK2 G2019S mutation PD, 117 non-manifesting carriers, 93 related noncarriers, and 40 healthy controls completed the Rapid eye movement sleep Behavior Disorder Screening Questionnaire. RESULTS Cut scores were met by 30.6% idiopathic PD, 19.7% LRRK2-PD, 6% nonmanifesting carriers, 20.4% related noncarriers, and 15% controls. The likelihood of abnormal scores was decreased in LRRK2-PD versus idiopathic PD (odds ratio = 0.55, P = 0.03), nonmanifesting carriers versus related noncarriers (OR = 0.25, P < 0.01), and PD of less than 3 years' duration, 1 of 19 LRRK2-PD versus 14 of 41 idiopathic PD (P < 0.05). CONCLUSIONS A lower frequency of abnormal questionnaire scores is seen in LRRK2-PD, especially in early LRRK2-PD, and in nonmanifesting carriers. Therefore, the Rapid eye movement sleep Behavior Disorder Questionnaire is unlikely to serve as a preclinical marker for phenoconversion to PD.

DOI: 10.1002/mds.26413
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@article{SaundersPullman2015REMSB, title={REM sleep behavior disorder, as assessed by questionnaire, in G2019S LRRK2 mutation PD and carriers.}, author={Rachel Saunders-Pullman and Roy N Alcalay and Anat Mirelman and Cuiling Wang and Marta San Luciano and Roberto A. Ortega and Amanda Glickman and Deborah Raymond and Helen Mejia-Santana and Nancy Doan and Brooke A Johannes and Kira Yasinovsky and Laurie Jean Ozelius and Lorraine N. Clark and Avi Orr-Utreger and Karen S. Marder and Nir Giladi and Susan B. Bressman}, journal={Movement disorders : official journal of the Movement Disorder Society}, year={2015}, volume={30 13}, pages={1834-9} }