REM-enhancing effects of the adrenergic antagonist idazoxan infused into the medial pontine reticular formation of the freely moving cat.

@article{Bier1994REMenhancingEO,
  title={REM-enhancing effects of the adrenergic antagonist idazoxan infused into the medial pontine reticular formation of the freely moving cat.},
  author={M J Bier and R. W. McCarley},
  journal={Brain research},
  year={1994},
  volume={634 2},
  pages={333-8}
}
Adrenergic input to the medial pontine reticular formation (mPRF) has been postulated to play an important role in behavioral state control. Previous work has shown that direct microinjections of the alpha 2 agonist clonidine and of norepinephrine into the mPRF suppress the REM phase of sleep. Here, we report that the alpha 2 antagonist idazoxan (IZ) enhances REM-like sleep states in the cat when microinfused into the rostral part of the mPRF at sites where carbachol produced a marked increase… CONTINUE READING