REM Sleep Deprivation Reverses Neurochemical and Other Depressive-Like Alterations Induced by Olfactory Bulbectomy

@article{Maturana2014REMSD,
  title={REM Sleep Deprivation Reverses Neurochemical and Other Depressive-Like Alterations Induced by Olfactory Bulbectomy},
  author={Maira J. Maturana and Cl{\'a}udia Pudell and Adriano D. S. Targa and Lais da Silva Rodrigues and Ana Carolina D. Noseda and Mariana Hernandes Fortes and Patr{\'i}cia dos Santos and Claudio da Cunha and Silvio Marques Zanata and Anete Curte Ferraz and Marcelo M S Lima},
  journal={Molecular Neurobiology},
  year={2014},
  volume={51},
  pages={349-360}
}
There is compelling evidence that sleep deprivation (SD) is an effective strategy in promoting antidepressant effects in humans, whereas few studies were performed in relevant animal models of depression. Acute administration of antidepressants in humans and rats generates a quite similar effect, i.e., suppression of rapid eye movement (REM) sleep. Then, we decided to investigate the neurochemical alterations generated by a protocol of rapid eye movement sleep deprivation (REMSD) in the notably… CONTINUE READING
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