REGULATION OF CYP1A1 GENE EXPRESSION BY THE ANTIOXIDANT TERT-BUTYLHYDROQUINONE

@article{Schreiber2006REGULATIONOC,
  title={REGULATION OF CYP1A1 GENE EXPRESSION BY THE ANTIOXIDANT TERT-BUTYLHYDROQUINONE},
  author={Thomas D. Schreiber and Christoph Koehle and Felicitas Buckler and Stefan Schmohl and Albert Braeuning and Alexander Schmiechen and Michael Schwarz and Peter A. Münzel},
  journal={Drug Metabolism and Disposition},
  year={2006},
  volume={34},
  pages={1096 - 1101}
}
CYP1A1, a major phase I enzyme, plays an important role in the metabolism of polycyclic aromatic hydrocarbons and in the chemical activation of xenobiotics to carcinogenic derivatives. The phenolic antioxidant tert-butylhydroquinone (tBHQ), often used as a food preservative, is generally considered to act only as a mono-functional inducer of phase II enzymes, thereby exerting chemo-protection. However, we recently observed that tBHQ elevated the activity of an aryl hydrocarbon receptor (AhR… 

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  • E. ZahnJ. Wolfrum S. Rieke
  • Biology
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2018

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