REGIONAL CHANGES IN CEREBRAL GABA CONCENTRATION AND CONVULSIONS PRODUCED BY d AND BY l‐ALLYLGLYCINE

@article{Horton1978REGIONALCI,
  title={REGIONAL CHANGES IN CEREBRAL GABA CONCENTRATION AND CONVULSIONS PRODUCED BY d AND BY l‐ALLYLGLYCINE},
  author={R. Horton and A. Chapman and B. Meldrum},
  journal={Journal of Neurochemistry},
  year={1978},
  volume={30}
}
  • R. Horton, A. Chapman, B. Meldrum
  • Published 1978
  • Chemistry, Medicine
  • Journal of Neurochemistry
    • Abstract— The convulsant action of allylglycine (2‐amino‐4‐pentenoic acid) is due to the metabolic conversion of allylglycine to 2‐keto‐4‐pentenoic acid, a more potent glutamic acid decarboxylase inhibitor and more potent convulsant than the parent compound. We report regional changes in cerebral GABA concentration in rats after administration of d‐ and l‐allylglycine. d‐Allylglycine (3.75 mmol/kg) induced convulsions in 95–115 min, characterised by repeated clonic limb movements and rapid… CONTINUE READING
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