REF6 recognizes a specific DNA sequence to demethylate H3K27me3 and regulate organ boundary formation in Arabidopsis

@article{Cui2016REF6RA,
  title={REF6 recognizes a specific DNA sequence to demethylate H3K27me3 and regulate organ boundary formation in Arabidopsis},
  author={Xia Cui and Falong Lu and Qi Qiu and Bing Zhou and Lianfeng Gu and Shuaibin Zhang and Yanyuan Kang and Xiekui Cui and Xuan Ma and Qingqing Yao and Jinbiao Ma and Xiaoyu Zhang and Xiaofeng Cao},
  journal={Nature Genetics},
  year={2016},
  volume={48},
  pages={694-699}
}
RELATIVE OF EARLY FLOWERING 6 (REF6, also known as JMJ12) counteracts Polycomb-mediated gene silencing by removing methyl groups from trimethylated histone H3 lysine 27 (H3K27me3) in hundreds of genes in Arabidopsis thaliana. Here we show that REF6 function and genome-wide targeting require its four Cys2His2 zinc fingers, which directly recognize a CTCTGYTY motif. Motifs bound by REF6 tend to cluster and reside in loci with active chromatin states. Furthermore, REF6 targets CUP-SHAPED COTYLEDON… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 14 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations

REF6 promotes lateral root formation through de-repression of PIN1/3/7 genes.

Journal of integrative plant biology • 2018
View 3 Excerpts
Highly Influenced

Cys2/His2 Zinc-Finger Proteins in Transcriptional Regulation of Flower Development

International journal of molecular sciences • 2018
View 2 Excerpts

References

Publications referenced by this paper.
Showing 1-10 of 43 references

C-terminal domains of a histone demethylase interact with a pair of transcription factors and mediate specific chromatin association

S Zhang
Cell Discovery • 2015

Similar Papers

Loading similar papers…