REDD2 expression in rat skeletal muscle correlates with nutrient-induced activation of mTORC1: responses to aging, immobilization, and remobilization.

@article{Kelleher2015REDD2EI,
  title={REDD2 expression in rat skeletal muscle correlates with nutrient-induced activation of mTORC1: responses to aging, immobilization, and remobilization.},
  author={Andrew R. Kelleher and Suzette L. Pereira and Leonard S. Jefferson and Scot R. Kimball},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2015},
  volume={308 2},
  pages={
          E122-9
        }
}
In a previous study (Kelleher AR, Kimball SR, Dennis MD, Schilder RJ, and Jefferson LS. Am J Physiol Endocrinol Metab 304: E229-236, 2013.), we observed a rapid (i.e., 1-3 days) immobilization-induced repression of mechanistic target of rapamycin complex 1 (mTORC1) signaling in hindlimb skeletal muscle of young (2-mo-old) rats that was associated with elevated expression of regulated in development and DNA-damage response (REDD) 1 and REDD2. The present study extends that observation to include… CONTINUE READING
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