RECQL1 and WRN proteins are potential therapeutic targets in head and neck squamous cell carcinoma.

@article{Arai2011RECQL1AW,
  title={RECQL1 and WRN proteins are potential therapeutic targets in head and neck squamous cell carcinoma.},
  author={Akihito Arai and Tokuhiro Chano and Kazunobu Futami and Yasuhiro Furuichi and Kaichiro Ikebuchi and Takuma Inui and Hitosuke Tameno and Yasuko Ochi and Taketoshi Shimada and Yasuo Hisa and Hidetoshi Okabe},
  journal={Cancer research},
  year={2011},
  volume={71 13},
  pages={4598-607}
}
RECQL1 and WRN proteins are RecQ DNA helicases that participate in suppression of DNA hyper-recombination and repair. In this study, we report evidence supporting their candidacy as cancer therapeutic targets. In hypopharyngeal carcinomas, which have the worst prognosis among head and neck squamous cell carcinomas (HNSCC) that are rapidly rising in incidence, we found that RECQL1 and WRN proteins are highly expressed and that siRNA-mediated silencing of either gene suppressed carcinoma cell… CONTINUE READING

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