RECQ5 helicase associates with the C-terminal repeat domain of RNA polymerase II during productive elongation phase of transcription

@inproceedings{Kanagaraj2010RECQ5HA,
  title={RECQ5 helicase associates with the C-terminal repeat domain of RNA polymerase II during productive elongation phase of transcription},
  author={Radhakrishnan Kanagaraj and Daniela Huehn and April L. MacKellar and Mirco Menigatti and Lu Zheng and V{\'a}clav Urban and Igor V. Shevelev and Arno L. Greenleaf and Pavel Janscak},
  booktitle={Nucleic acids research},
  year={2010}
}
It is known that transcription can induce DNA recombination, thus compromising genomic stability. RECQ5 DNA helicase promotes genomic stability by regulating homologous recombination. Recent studies have shown that RECQ5 forms a stable complex with RNA polymerase II (RNAPII) in human cells, but the cellular role of this association is not understood. Here, we provide evidence that RECQ5 specifically binds to the Ser2,5-phosphorylated C-terminal repeat domain (CTD) of the largest subunit of… CONTINUE READING
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