RECK gene expression in hepatocellular carcinoma: correlation with invasion-related clinicopathological factors and its clinical significance. Reverse-inducing--cysteine-rich protein with Kazal motifs.

@article{Furumoto2001RECKGE,
  title={RECK gene expression in hepatocellular carcinoma: correlation with invasion-related clinicopathological factors and its clinical significance. Reverse-inducing--cysteine-rich protein with Kazal motifs.},
  author={Katsuyoshi Furumoto and Shigeki Arii and A. Mori and Hiroaki Furuyama and M J Gorrin Rivas and Teizo Nakao and Naoki Isobe and Takehide Murata and Chiaki Takahashi and Makoto Noda and Masayuki Imamura},
  journal={Hepatology},
  year={2001},
  volume={33 1},
  pages={189-95}
}
The RECK (reversion-inducing-cysteine-rich protein with Kazal motifs) gene was initially isolated as a transformation suppressor gene. It encodes a membrane-anchored glycoprotein with multiple serine protease inhibitor-like domains. The RECK gene is expressed widely in normal organs but is undetectable in many tumor-derived cell lines. When artificially expressed in such cell lines, RECK suppresses their invasive and metastatic activities. Clinical implications of these findings, however… CONTINUE READING
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