RECAST (Remote Ischemic Conditioning After Stroke Trial): A Pilot Randomized Placebo Controlled Phase II Trial in Acute Ischemic Stroke.

@article{England2017RECASTI,
  title={RECAST (Remote Ischemic Conditioning After Stroke Trial): A Pilot Randomized Placebo Controlled Phase II Trial in Acute Ischemic Stroke.},
  author={Timothy J England and Amanda Hedstrom and Saoirse Elizabeth O'Sullivan and Richard G. Donnelly and David A. Barrett and Sarir Sarmad and Nikola Sprigg and Philip Michael William Bath},
  journal={Stroke},
  year={2017},
  volume={48 5},
  pages={1412-1415}
}
BACKGROUND AND PURPOSE Repeated episodes of limb ischemia and reperfusion (remote ischemic conditioning [RIC]) may improve outcome after acute stroke. METHODS We performed a pilot blinded placebo-controlled trial in patients with acute ischemic stroke, randomized 1:1 to receive 4 cycles of RIC within 24 hours of ictus. The primary outcome was tolerability and feasibility. Secondary outcomes included safety, clinical efficacy (day 90), putative biomarkers (pre- and post-intervention, day 4… CONTINUE READING
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HSP27 protects the blood-brain barrier against ischemia-induced loss of integrity.

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