REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics

@inproceedings{CarhartHarris2019REBUSAT,
  title={REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics},
  author={Robin L Carhart-Harris and Karl J. Friston},
  booktitle={Pharmacological reviews},
  year={2019}
}
This paper formulates the action of psychedelics by integrating the free-energy principle and entropic brain hypothesis. We call this formulation relaxed beliefs under psychedelics (REBUS) and the anarchic brain, founded on the principle that-via their entropic effect on spontaneous cortical activity-psychedelics work to relax the precision of high-level priors or beliefs, thereby liberating bottom-up information flow, particularly via intrinsic sources such as the limbic system. We assemble… CONTINUE READING
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