REACTION MECHANISMS IN THE RADIOLYSIS OF PEPTIDES, POLYPEPTIDES AND PROTEINS II REACTIONS AT SIDE-CHAIN LOCI IN MODEL SYSTEMS

@inproceedings{Garrison1982REACTIONMI,
  title={REACTION MECHANISMS IN THE RADIOLYSIS OF PEPTIDES, POLYPEPTIDES AND PROTEINS II REACTIONS AT SIDE-CHAIN LOCI IN MODEL SYSTEMS},
  author={Warren M. Garrison},
  year={1982}
}
The purpose of this review is to bring together and to correlate the wide variety of experimental studies that provide information on the reaction products and reaction mechanisms involved in the radiolysis of peptides, polypeptides and proteins (including chromosomal proteins) in both aqueous and solid-state systems. The comparative radiation chemistry of these systems is developed in terms of specific reactions of the peptide main-chain and the aliphatic, aromatic-unsaturated and sulfur… 

Chemical Modification of Proteins by Reactive Oxygen Species

The presence of 4• Q2 aminobutyric acid in acid hydrolysates of proteins is presumptive evidence for peptide cleavage by the 2-pyrrolidone pathway.

Selectivity in ROS-induced peptide backbone bond cleavage.

Comparisons of reaction enthalpies show that the diamide pathway is more energetically favorable than the α-amidation pathway and that both pathways are site and conformationally selective, which readily contribute to the understanding of oxidative stress in biochemical processes.

Photo-induced electron transfer in small peptides: glycylalanine

Unlike XG peptides, glycylalanine degrades to acetamide substantially without co-production of CO2 and to products where bonding in the side-chain is involved in relaxation of the intermediate diradical.

C-N bond cleavage reactions on the radiolysis of amino-containing organic compounds and their derivatives in aqueous solutions

The most effective processes leading to the C-N bond cleavage on the radiolysis of aqueous solutions of amino-containing organic compounds are those in which the key role is played by reactions of monomolecular decomposition of radicals of the initial compounds.

Radiation-induced degradation of hydroxyl-containing amino acids in aqueous solutions

The set of data presented in this work shows that the radiolysis of hydroxyl-containing amino acids in aqueous solutions results in their degradation with -C-C- bond cleavage, which leads to both the

A sensitive chemical procedure for monitoring the radiolytic oxidation of proteins at γ-ray dosages down to 1 Krad

This is a sensitive chemical-spectrophotometric procedure for quantitatively monitoring G(>CO)t over a dose range of interest in radiation biology (1 to 50 Krad).

Free Radical Transfer Involving Sulphur Peptide Functions

The specific structures of electron transfer pro­teins, and particularly the environment around the active sites, are thought to play a perti­nent role in directing the electron transfer process, and various possible mechanisms of elec­tron transfer through the protein matrix have been discussed.

Deamination and degradation of hydroxyl-containing dipeptides and tripeptides in the radiolysis of their aqueous solutions

The effect of the presence of hydroxyl groups at the side chains of di- and tripeptides on the radiation-initiated deamination and main-chain cleavage was examined. It was found that the presence of
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    International journal of radiation biology and related studies in physics, chemistry, and medicine
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Gamma-Radiolysis was applied to estimate relative yields of formation of 2,2'-biphenols under various conditions, and about 60 per cent of the Gly-Tyr phenoxyls were found to dimerize to the 2, 2'- biphenol, and a similarly efficient 2,1'-coupling seems to occur with other tyrosyls, such as Lys-Tyrs and histone.

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Rates of reactions of OH and HO/sub 2/ with organic and inorganic molecules, ions and transients in aqueous solution have been tabulated, as well as the rates for the corresponding radical ions in
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