RCC1 isoforms differ in their affinity for chromatin, molecular interactions and regulation by phosphorylation.

@article{Hood2007RCC1ID,
  title={RCC1 isoforms differ in their affinity for chromatin, molecular interactions and regulation by phosphorylation.},
  author={Fiona E. Hood and Paul R. Clarke},
  journal={Journal of cell science},
  year={2007},
  volume={120 Pt 19},
  pages={
          3436-45
        }
}
RCC1 is the guanine nucleotide exchange factor for Ran GTPase. Generation of Ran-GTP by RCC1 on chromatin provides a spatial signal that directs nucleocytoplasmic transport, mitotic spindle assembly and nuclear envelope formation. We show that RCC1 is expressed in human cells as at least three isoforms, named RCC1alpha, RCC1beta and RCC1gamma, which are expressed at different levels in specific tissues. The beta and gamma isoforms contain short inserts in their N-terminal regions (NTRs) that… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 20 CITATIONS

Self-organization of intracellular gradients during mitosis

  • Cell Division
  • 2009
VIEW 7 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

The role of RanGTP gradient in vertebrate oocyte maturation.

  • Results and problems in cell differentiation
  • 2011
VIEW 3 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Inhibition of Karyopherin beta 1 suppresses prostate cancer growth

Jian Yang, Yuqi Guo, +9 authors Xin Li
  • Oncogene
  • 2019
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 46 REFERENCES

Molecular mechanism of the nuclear protein import cycle

M. Stewart
  • Nat . Rev . Mol . Cell Biol .
  • 2007