RBPjkappa-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development.

@article{Dong2010RBPjkappadependentNS,
  title={RBPjkappa-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development.},
  author={Yufeng Dong and Alana M Jesse and Anat Kohn and Lea M Gunnell and T. Honjo and Michael J Zuscik and Regis J O'Keefe and Matthew J Hilton},
  journal={Development},
  year={2010},
  volume={137 9},
  pages={
          1461-71
        }
}
The Notch pathway has recently been implicated in mesenchymal progenitor cell (MPC) differentiation from bone marrow-derived progenitors. However, whether Notch regulates MPC differentiation in an RBPjkappa-dependent manner, specifies a particular MPC cell fate, regulates MPC proliferation and differentiation during early skeletal development or controls specific Notch target genes to regulate these processes remains unclear. To determine the exact role and mode of action for the Notch pathway… CONTINUE READING
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