RBPJkappa-dependent signaling is essential for long-term maintenance of neural stem cells in the adult hippocampus.

@article{Ehm2010RBPJkappadependentSI,
  title={RBPJkappa-dependent signaling is essential for long-term maintenance of neural stem cells in the adult hippocampus.},
  author={Oliver Ehm and Christian G{\"o}ritz and Marcela Covic and Iris Schaeffner and Tobias Schwarz and Esra Karaca and Bettina Kempkes and Elisabeth Kremmer and Frank W Pfrieger and L. Manzano Espinosa and Anna Bigas and Claudio Giachino and Verdon Taylor and Jonas Fris{\'e}n and Dieter Chichung Lie},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2010},
  volume={30 41},
  pages={13794-807}
}
The generation of new neurons from neural stem cells in the adult hippocampal dentate gyrus contributes to learning and mood regulation. To sustain hippocampal neurogenesis throughout life, maintenance of the neural stem cell pool has to be tightly controlled. We found that the Notch/RBPJκ-signaling pathway is highly active in neural stem cells of the adult mouse hippocampus. Conditional inactivation of RBPJκ in neural stem cells in vivo resulted in increased neuronal differentiation of neural… CONTINUE READING
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