RBP1 induces growth arrest by repression of E2F-dependent transcription

@article{Lai1999RBP1IG,
  title={RBP1 induces growth arrest by repression of E2F-dependent transcription},
  author={Albert Lai and Richard Marcellus and Hughes B Corbeil and Philip E. Branton},
  journal={Oncogene},
  year={1999},
  volume={18},
  pages={2091-2100}
}
Growth arrest and cell cycle progression are regulated by the retinoblastoma tumour suppressor pRB and related proteins p130 and p107 that bind to and inhibit the E2F family of transcription factors. Although the precise mechanism of this inhibition remains to be established, previous studies indicated the presence of transcriptional repression activity in the `pocket' of RB family members. We show here that RBP1, a known pRB pocket-binding protein, possesses transcriptional repression activity… CONTINUE READING
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