RBM7 subunit of the NEXT complex binds U-rich sequences and targets 3′-end extended forms of snRNAs

  title={RBM7 subunit of the NEXT complex binds U-rich sequences and targets 3′-end extended forms of snRNAs},
  author={Dominika Hro{\vs}{\vs}ov{\'a} and Tomas Sikorsky and David Potě{\vs}il and Marek Bartosovic and Josef Pasulka and Zbyněk Zdr{\'a}hal and Richard Stefl and Stepanka Vanacova},
  booktitle={Nucleic acids research},
The Nuclear Exosome Targeting (NEXT) complex is a key cofactor of the mammalian nuclear exosome in the removal of Promoter Upstream Transcripts (PROMPTs) and potentially aberrant forms of other noncoding RNAs, such as snRNAs. NEXT is composed of three subunits SKIV2L2, ZCCHC8 and RBM7. We have recently identified the NEXT complex in our screen for oligo(U) RNA-binding factors. Here, we demonstrate that NEXT displays preference for U-rich pyrimidine sequences and this RNA binding is mediated by… CONTINUE READING
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