RBM5/Luca-15/H37 regulates Fas alternative splice site pairing after exon definition.

  title={RBM5/Luca-15/H37 regulates Fas alternative splice site pairing after exon definition.},
  author={Sophie Bonnal and Concepci{\'o}n Reynaldo Mart{\'i}nez and Patrik Foerch and Angela Bachi and Matthias Wilm and Juan Valc{\'a}rcel},
  journal={Molecular cell},
  volume={32 1},
RBM5/Luca-15/H37 is a gene frequently inactivated in lung cancers and overexpressed in breast tumors. Its protein product has been detected in prespliceosomal complexes and modulates cell proliferation and Fas-mediated apoptosis. We report that RBM5 is a component of complexes involved in 3' splice site recognition and regulates alternative splicing of apoptosis-related genes, including the Fas receptor, switching between isoforms with antagonistic functions in programmed cell death. In… CONTINUE READING
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