RBM4 Promotes Pancreas Cell Differentiation and Insulin Expression

@article{Lin2012RBM4PP,
  title={RBM4 Promotes Pancreas Cell Differentiation and Insulin Expression},
  author={Jung-Chun Lin and Yu-Ting Yan and Wen-Kou Hsieh and Pey-Jey Peng and Chun-Hao Su and W. Tarn},
  journal={Molecular and Cellular Biology},
  year={2012},
  volume={33},
  pages={319 - 327}
}
ABSTRACT The RNA-binding protein RNA-binding motif protein 4 (RBM4) modulates alternative splicing of muscle-specific mRNA isoforms during muscle cell differentiation. To better understand the physiological function of RBM4, we exploited a gene knockout strategy in the present study. Mice with targeted disruption of one of the two Rbm4 genes exhibited hyperglycemia coincident with reduced levels of serum insulin and reduced size of pancreatic islets. The embryonic pancreases of Rbm4-deficient… Expand
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References

SHOWING 1-10 OF 39 REFERENCES
Combined expression of transcription factors induces AR42J-B13 cells to differentiate into insulin-producing cells.
Regulation of insulin gene transcription
Multiple roles of RBM4 in muscle cell differentiation.
Expression of dominant negative form of PAX4 in human insulinoma.
Chronic hyperglycemia impairs insulin secretion by affecting insulin receptor expression, splicing, and signaling in RIN β‐cell line and human islets of Langerhans
  • M. Hribal, L. Perego, +18 authors G. Sesti
  • Biology, Medicine
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2003
Regulation of PKD by the MAPK p38δ in Insulin Secretion and Glucose Homeostasis
Insulin Gene Expression Is Regulated by DNA Methylation
Exon Selection in α-Tropomyosin mRNA Is Regulated by the Antagonistic Action of RBM4 and PTB
Exon selection in alpha-tropomyosin mRNA is regulated by the antagonistic action of RBM4 and PTB.
Glucose Regulation of Insulin Gene Transcription and Pre-mRNA Processing in Human Islets
...
1
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3
4
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