RBM4 Promotes Pancreas Cell Differentiation and Insulin Expression

@article{Lin2012RBM4PP,
  title={RBM4 Promotes Pancreas Cell Differentiation and Insulin Expression},
  author={Jung-Chun Lin and Yu-Ting Yan and Wen-Kou Hsieh and Pey-Jey Peng and Chun-Hao Su and Woan-Yuh Tarn},
  journal={Molecular and Cellular Biology},
  year={2012},
  volume={33},
  pages={319 - 327}
}
ABSTRACT The RNA-binding protein RNA-binding motif protein 4 (RBM4) modulates alternative splicing of muscle-specific mRNA isoforms during muscle cell differentiation. To better understand the physiological function of RBM4, we exploited a gene knockout strategy in the present study. Mice with targeted disruption of one of the two Rbm4 genes exhibited hyperglycemia coincident with reduced levels of serum insulin and reduced size of pancreatic islets. The embryonic pancreases of Rbm4-deficient… 
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