RB1CC1 activates the promoter and expression of RB1 in human cancer.

@article{Ikebuchi2009RB1CC1AT,
  title={RB1CC1 activates the promoter and expression of RB1 in human cancer.},
  author={Kaichiro Ikebuchi and Tokuhiro Chano and Yasuko Ochi and Hitosuke Tameno and Taketoshi Shimada and Yasuo Hisa and Hidetoshi Okabe},
  journal={International journal of cancer},
  year={2009},
  volume={125 4},
  pages={861-7}
}
RB1-inducible coiled-coil 1 (RB1CC1, also known as FIP200) is a tumor suppressor implicated in the regulation of RB1 (retinoblastoma 1) expression. However, the molecular mechanism of RB1 regulation by RB1CC1 has not been elucidated. Here, we demonstrate that nuclear RB1CC1 binds to the RB1 promoter using chromatin immunoprecipitation assays with anti… CONTINUE READING